一、時 間： 2012年12月3日（星期一）下午2:30
二、地 點： 國家重點學(xué)科實驗室大樓8樓學(xué)術(shù)活動室
三、報告題目與主持人
（一）Platelet activation and Thrombolytic therapy: Pathogenesis and treatment of heart attack and stroke
Frederick A. Ofosu MD, PhD
Professor，McMaster University, Canada
主持人：胡質(zhì)毅博士、教授
（二）How I treat cardiovascular diseases (or TBA)
Dr. George S. Lavenson MD, PhD
Diplomate American Board of Surgery, University of Hawaii, USA
主持人：胡質(zhì)毅博士、教授
（三）Platelets are vesitile cells: Roles of platelets in hemostasis, inflammation, and cardiovascular diseases
Heyu Ni（倪合宇） MD, PhD
Professor，Department of Physiology at the University of Toronto, Canada.
主持人：潘華峰博士、教授
四、報告人簡介：
倪博士在加拿大Manitoba大學(xué)獲得免疫學(xué)博士學(xué)位，之后在美國哈佛醫(yī)學(xué)院完成博士后研究。目前在加拿大Toronto大學(xué)主要從事有關(guān)粘附分子在止血和血栓方面的科研工作，同時，他的實驗室也在異常和自身免疫疾病涉及到的出血紊亂的研究中也有較好成果。主持由Canadian Institutes of Health Research (CIHR), Heart，Stroke Foundation of Canada (HSFC)，Canadian Blood Services (CBS)和Canadian Foundation for Innovation (CFI)資助的多項科研項目。近年來在PNAS, Blood， Journal of Thrombosis 和 Journal of Experimental Medicine等主流雜志上，以通訊作者等身份發(fā)表40余篇文章。 現(xiàn)為 Blood，Journal of Clinical Investigation，Journal of Biological Chemistry，Arteriosclerosis，Thrombosis和 Vascular Biology等12個國際期刊的獨立審稿人。
五、報告摘要：
Platelets play key roles in hemostasis and thrombosis. Recent studies found that platelets contain significant amounts of P-selectin, TLRs, CD40/CD40L, TGF-b and other inflammatory factors. They also contain both pro- and anti-angiogenic factors. Thus, platelets are versatile cells and significantly contribute to inflammation, immune responses, and angiogenesis. We further demonstrated that Fg/VWF-independent platelet aggregation can be induced in vitro under more physiological conditions (i.e. non-anticoagulated blood) and that b3 integrin (GPIIbIIIa) is the platelet receptor required for this non-classical mechanism of platelet aggregation. Interestingly, although no alterations has been observed in levels of plasma fibronectin (pFn), thrombospondin-1, and vitronectin in Fg/VWF-/- mice, platelet fibronectin contents are markedly increased in fibrinogen deficient mice and human patients. To examine whether plasma fibronectin (pFn) is the alternative b3 integrin ligand mediating this novel platelet aggregation pathway, we generated Fg/VWF/pFn-/- triple knockout mice. Surprisingly, platelet aggregation and thrombus formation in Fg/VWF/pFn-/- mice were not abolished but were enhanced, as compared with Fg/VWF-/- mice. Our data demonstrate that pFn is a supportive factor in hemostasis but a regulatory factor in thrombosis. Several novel ligands of b3 integrin have been identified and their roles in thrombosis and hemostasis are studied.
熱烈歡迎廣大師生參加！
研究生院、211辦
2012.12.01
